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In-situ one step synthesis of polymer functionalized palladium nanoparticles: An efficient anticancer agent against breast cancer

Abstract

Breast cancer is the most common malignancies among women in worldwide and the researchers working for the effective treatment to eradicate the breast cancer. In the present study, we prepared PVP functionalized palladium nanoparticles (PVP-PdNPs) for the treatment of human breast cancer MCF7 cells. Initially, the PVP functionalized PdNPs were synthesized by in situ method and confirmed with DRS-UV spectrometric analysis. Further, the FTIR and Raman spectroscopic analyses showed the association of PVP with PdNPs by showing the vibrational mode for PdNPs and C═O stretch and CH2 band for PVP. The microscopic analysis showed the PVP-PdNPs has narrow distribution with spherical in shape and the size range between 9-15 nm. The SAED and XRD pattern confirmed the crystalline structure is face-centered cubic in nature and the Edax mapping confirmed the formulation of PVP on the surface of the PdNPs. Further, the in vitro MTT assay analysis showed the PVP-PdNPs exhibits excellent cytotoxic activity against human breast cancer MCF7 cells in dose-dependent manner. The PVP-PdNPs generate continuous ROS in the mitochondria that leads to damage the mitochondrial membrane potential, nuclear DNA and induce apoptosis through caspase3/7 enzymatic activity. Together, the PVP-PdNPs promising a potential anticancer agent against human breast cancer.

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Article information


Submitted
29 Nov 2019
Accepted
13 Feb 2020
First published
14 Feb 2020

Dalton Trans., 2020, Accepted Manuscript
Article type
Paper

In-situ one step synthesis of polymer functionalized palladium nanoparticles: An efficient anticancer agent against breast cancer

V. Ramalingam, S. Raja and M. Harshavardhan, Dalton Trans., 2020, Accepted Manuscript , DOI: 10.1039/C9DT04576G

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