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Harnessing the active site triad: merging hemilability, proton responsivity, and ligand-based redox-activity

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Abstract

Metalloenzymes catalyze many important reactions by managing the proton and electron flux at the enzyme active site. The motifs utilized to facilitate these transformations include hemilabile, redox-active, and so called proton responsive sites. Given the importance of incorporating and understanding these motifs in the area of coordination chemistry and catalysis, we highlight recent milestones in the field. Work incorporating the triad of hemilability, redox-activity, and proton responsivity into single ligand scaffolds will be described.

Graphical abstract: Harnessing the active site triad: merging hemilability, proton responsivity, and ligand-based redox-activity

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Article information


Submitted
20 Nov 2019
Accepted
16 Dec 2019
First published
07 Jan 2020

Dalton Trans., 2020, Advance Article
Article type
Frontier

Harnessing the active site triad: merging hemilability, proton responsivity, and ligand-based redox-activity

D. F. Baumgardner, W. E. Parks and J. D. Gilbertson, Dalton Trans., 2020, Advance Article , DOI: 10.1039/C9DT04470A

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