Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour

Heiko Geisler; Debora Wernitznig; Michaela Hejl; Natalie Gajic; Michael A. Jakupec; Wolfgang Kandioller; Bernhard K. Keppler

doi:10.1039/C9DT04462K

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour†

Heiko Geisler,

^a Debora Wernitznig,

^a Michaela Hejl,^a Natalie Gajic,^a Michael A. Jakupec,

^ab Wolfgang Kandioller

*^ab and Bernhard K. Keppler

^ab

Author affiliations

* Corresponding authors

^a University of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry, Waehringer Str. 42, A-1090 Vienna, Austria
E-mail: wolfgang.kandioller@univie.ac.at
Tel: +43 1 4277 52609

^b Research Cluster “Translational Cancer Therapy Research”, University of Vienna, Waehringer Str. 42, A-1090 Vienna, Austria

Abstract

Novel phthiocol-based organometallics with in situ formed tridentate N,O,O-coordination motif were established via three-component microwave assisted one-pot reaction. These complexes exhibited enhanced stability in aqueous solution compared to the parental compound KP2048 and showed unexpected cytotoxic behaviour and selectivity in 2D and 3D cell cultures.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/C9DT04462K
Article type: Communication
Submitted: 19 Nov 2019
Accepted: 08 Jan 2020
First published: 17 Jan 2020
This article is Open Access

Download Citation

Dalton Trans., 2020,49, 1393-1397

Permissions

Request permissions

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour

H. Geisler, D. Wernitznig, M. Hejl, N. Gajic, M. A. Jakupec, W. Kandioller and B. K. Keppler, Dalton Trans., 2020, 49, 1393 DOI: 10.1039/C9DT04462K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Dalton Transactions

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour

Social activity

Search articles by author

Spotlight

Advertisements