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Recent Advances in Wacker Oxidation: From Conventional to Modern Variants and Applications

Abstract

This review accentuates the recent developments in the Wacker oxidation from its conventional form to the more efficient, economical and greener method established in last five years (2015-2020). The Wacker oxidation involves the synthesis of aldehyde or methyl ketone from terminal olefin following Markovnikov or anti-Markonikov addition of water by using palladium-based catalysts. The development of catalysts from Pd to other metals and choice of more eco-friendly and economical oxidants has been investigated recently, which pledges ingress to synthesis of more functionalized ketones and aldehydes. The extension to aza-Wacker-type oxidation is new dimension to this field. The effect of substituents on regioselectivity of the reaction has been well illustrated. The choice of various secondary oxidants has been focused in this review. The wide applicability of newer modes along with conventional conditions of Wacker oxidation in synthesis of natural products and valuable compounds recently is another dimension covered to validate the potential of this well-known reaction

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Article information


Accepted
04 Oct 2020
First published
05 Oct 2020

Catal. Sci. Technol., 2020, Accepted Manuscript
Article type
Minireview

Recent Advances in Wacker Oxidation: From Conventional to Modern Variants and Applications

R. A. Fernandes, A. K. Jha and P. Kumar, Catal. Sci. Technol., 2020, Accepted Manuscript , DOI: 10.1039/D0CY01820A

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