Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Palladium-catalysed Heck-type alkenylation reactions in the synthesis of quinolines. Mechanistic insights and recent applications

Abstract

Quinoline and quinolone cores are present in a wide variety of pharmaceuticals, agrochemicals and materials, as well in ligands/catalysts in asymmetric synthesis. Transition-metal catalysed based approaches have played a pivotal role in the development of the catalytic methods for their synthesis. This review presents recent developments on palladium-catalysed Mizoroki-Heck reaction and its dehydrogenative variant (the Fujiwara-Moritani reaction), a C-H activation reaction that does not require the use of prefunctionalized coupling parterns for the synthesis of quinoline frameworks. The mechanistic understanding of both type of reactions, and how the different reaction conditions affect the outcome and the regioselectivity for the synthesis of the quinoline core, which is crucial to achieve target-oriented synthesis successfully, is discussed through selected examples

Back to tab navigation

Article information


Submitted
17 Apr 2020
Accepted
15 May 2020
First published
18 May 2020

Catal. Sci. Technol., 2020, Accepted Manuscript
Article type
Minireview

Palladium-catalysed Heck-type alkenylation reactions in the synthesis of quinolines. Mechanistic insights and recent applications

A. Carral-Menoyo, N. Sotomayor and E. Lete, Catal. Sci. Technol., 2020, Accepted Manuscript , DOI: 10.1039/D0CY00789G

Social activity

Search articles by author

Spotlight

Advertisements