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Catalysis, kinetics and mechanisms of organo-iridium enantioselective hydrogenation-reduction

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Abstract

The synthesis of chiral molecules is of great importance to the pharmaceutical, agrochemical, flavour and fragrance industries. The use of organo-iridium complexes has gained a reputation for its great utility in key enantioselective synthetic procedures. Prime examples include the catalytic reduction of carbonyls and imines; iridium-catalysed allylic substitution and catalysed enantioselective hydrogenation of unsaturated carboxylic acids. Important aspects in these processes are the reaction conditions such as the catalyst loading, metal-ion ligands, the substrate, solvent and the reaction times-all of which can affect the degree of enantioselectivity. Understanding the mechanisms of these hydrogenation/reduction reactions through kinetic and other related studies makes a vital contribution to improving catalytic efficiency.

Graphical abstract: Catalysis, kinetics and mechanisms of organo-iridium enantioselective hydrogenation-reduction

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Article information


Submitted
24 Oct 2019
Accepted
11 Dec 2019
First published
11 Dec 2019

This article is Open Access

Catal. Sci. Technol., 2020, Advance Article
Article type
Minireview

Catalysis, kinetics and mechanisms of organo-iridium enantioselective hydrogenation-reduction

J. M. Mwansa and M. I. Page, Catal. Sci. Technol., 2020, Advance Article , DOI: 10.1039/C9CY02147G

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