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Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions

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Abstract

Cleavage of C–O and C–N bonds mediated by transition metals is a promising bioorthogonal approach to rescue the activity of caged molecules, such as proteins and cytotoxic drugs, under biological conditions. However, the precise mechanism of such uncaging reactions remains elusive. This review provides mechanistic insights into metal-mediated bond-cleavage reactions, with the goals of understanding the main factors that influence the reaction and aiding the rational development of new caging groups/catalysts for chemical biology and drug-delivery applications.

Graphical abstract: Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions

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Article information


Submitted
30 May 2020
First published
07 Oct 2020

Chem. Soc. Rev., 2020, Advance Article
Article type
Review Article

Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions

E. Latocheski, G. M. Dal Forno, T. M. Ferreira, B. L. Oliveira, G. J. L. Bernardes and J. B. Domingos, Chem. Soc. Rev., 2020, Advance Article , DOI: 10.1039/D0CS00630K

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