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Genetic alphabet expansion technology by creating unnatural base pairs

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Abstract

Recent advancements in the creation of artificial extra base pairs (unnatural base pairs, UBPs) are opening the door to a new research area, xenobiology, and genetic alphabet expansion technologies. UBPs that function as third base pairs in replication, transcription, and/or translation enable the site-specific incorporation of novel components into DNA, RNA, and proteins. Here, we describe the UBPs developed by three research teams and their application in PCR-based diagnostics, high-affinity DNA aptamer generation, site-specific labeling of RNAs, semi-synthetic organism creation, and unnatural-amino-acid-containing protein synthesis.

Graphical abstract: Genetic alphabet expansion technology by creating unnatural base pairs

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Article information


Submitted
28 Apr 2020
First published
05 Oct 2020

Chem. Soc. Rev., 2020, Advance Article
Article type
Review Article

Genetic alphabet expansion technology by creating unnatural base pairs

M. Kimoto and I. Hirao, Chem. Soc. Rev., 2020, Advance Article , DOI: 10.1039/D0CS00457J

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