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Issue 22, 2020
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Scalable biocatalytic C–H oxyfunctionalization reactions

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Abstract

Catalytic C–H oxyfunctionalization reactions have garnered significant attention in recent years with their ability to streamline synthetic routes toward complex molecules. Consequently, there have been significant strides in the design and development of catalysts that enable diversification through C–H functionalization reactions. Enzymatic C–H oxygenation reactions are often complementary to small molecule based synthetic approaches, providing a powerful tool when deployable on preparative-scale. This review highlights key advances in scalable biocatalytic C–H oxyfunctionalization reactions developed within the past decade.

Graphical abstract: Scalable biocatalytic C–H oxyfunctionalization reactions

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Article information


Submitted
24 Apr 2020
First published
23 Jul 2020

Chem. Soc. Rev., 2020,49, 8137-8155
Article type
Review Article

Scalable biocatalytic C–H oxyfunctionalization reactions

S. Chakrabarty, Y. Wang, J. C. Perkins and A. R. H. Narayan, Chem. Soc. Rev., 2020, 49, 8137 DOI: 10.1039/D0CS00440E

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