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Issue 21, 2020
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Bioapplications of small molecule Aza-BODIPY: from rational structural design to in vivo investigations

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Abstract

Boron-dipyrromethene (BODIPY) belongs to a family of organoboron compounds, commercialized as fluorescent dyes by Invitrogen™. As BODIPY derivatives, Aza-boron-dipyrromethene (Aza-BODIPY) dyes display superior spectral performances, such as red-shifted spectra and high molar extinction coefficients, and are considered to be extremely attractive organic materials for various bioapplications. Therefore, scientists from different disciplinary backgrounds would benefit from a review that provides a timely summary and outlook regarding Aza-BODIPY dyes. In this review, we report on the latest advances of Aza-BODIPY dyes, along with the empirical design guidelines and photophysical property manipulation of these dyes. In addition, we will discuss the biological applications of Aza-BODIPY dyes in probing various biological activities, as well as in fluorescence bioimaging/detection, newly-emerging photoacoustic bioimaging/detection, and phototherapy together with future challenges and implications in this field. We aim at providing an insightful design guideline and a clear overview of Aza-BODIPY dyes, which might entice new ideas and directions.

Graphical abstract: Bioapplications of small molecule Aza-BODIPY: from rational structural design to in vivo investigations

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Article information


Submitted
24 May 2020
First published
30 Sep 2020

Chem. Soc. Rev., 2020,49, 7533-7567
Article type
Review Article

Bioapplications of small molecule Aza-BODIPY: from rational structural design to in vivo investigations

Z. Shi, X. Han, W. Hu, H. Bai, B. Peng, L. Ji, Q. Fan, L. Li and W. Huang, Chem. Soc. Rev., 2020, 49, 7533
DOI: 10.1039/D0CS00234H

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