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Iron catalysts with N-ligands for carbene transfer of diazo reagents

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Abstract

Transition-metal-catalyzed carbene transfer reactions, involving diazo compounds and their precursors, are powerful tools for creating new C–C bonds. Depending on the involved catalytic system, the carbene insertion can efficiently be driven towards a specific functional group for the synthesis of a wide portfolio of fine chemicals. The present report is focused on the catalytic activity of iron catalysts in promoting alkene cyclopropanations, C–H and X–H (X = N, O, S, Se, Si, Sn, Ge) functionalizations. Porphyrin, porphyrinoid and non-heme iron complexes are discussed by analyzing experimental studies and theoretical calculations performed for proposing reaction mechanisms. The catalytic activity of artificial iron biocatalysts is also briefly reported in order to underline the similarities and differences between reaction mechanisms mediated by modified biocatalysts and synthetic catalysts. This review summarizes the achievements made in this field since 2006.

Graphical abstract: Iron catalysts with N-ligands for carbene transfer of diazo reagents

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Article information


Submitted
10 Mar 2020
First published
12 Jun 2020

Chem. Soc. Rev., 2020, Advance Article
Article type
Review Article

Iron catalysts with N-ligands for carbene transfer of diazo reagents

C. Damiano, P. Sonzini and E. Gallo, Chem. Soc. Rev., 2020, Advance Article , DOI: 10.1039/D0CS00221F

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