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Influence of nanomedicine mechanical properties on tumor targeting delivery

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Abstract

Modulating nanomedicine mechanical properties for enhanced drug delivery to tumors has attracted increasing attention in the past few decades. In this tutorial review, we analyze the impact of nanomedicine mechanical properties on in vivo transport processes and highlight the most recent advances in drug delivery efficiency and antitumor efficacy. Typical nanoparticles that have been explored for this purpose since 2000 are summarized while the methods to tune and the techniques to characterize nanomedicine mechanical properties are introduced. In the end, challenges and perspectives on tailoring nanomedicine mechanical properties for tumor targeting delivery are discussed.

Graphical abstract: Influence of nanomedicine mechanical properties on tumor targeting delivery

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Article information


Submitted
18 Jan 2020
First published
26 Mar 2020

Chem. Soc. Rev., 2020, Advance Article
Article type
Tutorial Review

Influence of nanomedicine mechanical properties on tumor targeting delivery

Z. Li, C. Xiao, T. Yong, Z. Li, L. Gan and X. Yang, Chem. Soc. Rev., 2020, Advance Article , DOI: 10.1039/C9CS00575G

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