Jump to main content
Jump to site search


Synthetic ratiometric fluorescent probes for detection of ions

Author affiliations

Abstract

Metal cations and anions are essential for versatile physiological processes. Dysregulation of specific ion levels in living organisms is known to have an adverse effect on normal biological events. Owing to the pathophysiological significance of ions, sensitive and selective methods to detect these species in biological systems are in high demand. Because they can be used in methods for precise and quantitative analysis of ions, organic dye-based ratiometric fluorescent probes have been extensively explored in recent years. In this review, recent advances (2015–2019) made in the development and biological applications of synthetic ratiometric fluorescent probes are described. Particular emphasis is given to organic dye-based ratiometric fluorescent probes that are designed to detect biologically important and relevant ions in cells and living organisms. Also, the fundamental principles associated with the design of ratiometric fluorescent probes and perspectives about how to expand their biological applications are discussed.

Graphical abstract: Synthetic ratiometric fluorescent probes for detection of ions

Back to tab navigation

Publication details

The article was received on 30 Jul 2019 and first published on 21 Nov 2019


Article type: Review Article
DOI: 10.1039/C9CS00243J
Chem. Soc. Rev., 2020, Advance Article

  •   Request permissions

    Synthetic ratiometric fluorescent probes for detection of ions

    S. Park, N. Kwon, J. Lee, J. Yoon and I. Shin, Chem. Soc. Rev., 2020, Advance Article , DOI: 10.1039/C9CS00243J

Search articles by author

Spotlight

Advertisements