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The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

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Abstract

Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review.

Graphical abstract: The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

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Article information


Submitted
06 Oct 2019
First published
17 Dec 2019

Chem. Soc. Rev., 2020, Advance Article
Article type
Tutorial Review

The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

P. Lo, M. S. Rodríguez-Morgade, R. K. Pandey, D. K. P. Ng, T. Torres and F. Dumoulin, Chem. Soc. Rev., 2020, Advance Article , DOI: 10.1039/C9CS00129H

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