Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 1, 2020
Previous Article Next Article

Chiral phosphoric acid-catalyzed asymmetric dearomatization reactions

Author affiliations

Abstract

We summarize in this review the recent development of chiral phosphoric acid (CPA)-catalyzed asymmetric dearomatization reactions. A wide array of electron-rich arenes (indoles, phenols, naphthols, benzothiophenes, benzofurans, etc.) and electron-poor arenes (pyridines, quinolines, isoquinolines, etc.) has been proved reactive towards various reaction partners in the presence of a CPA catalyst, enabling asymmetric dearomatization reactions that lead to structurally-diverse polycyclic molecules. The reactions are grouped according to the roles of the arenes in the reactions (as nucleophiles or electrophiles) and the types of reaction partners. This review closes with a personal perspective on the dynamic research area of asymmetric dearomatization reactions by CPAs.

Graphical abstract: Chiral phosphoric acid-catalyzed asymmetric dearomatization reactions

Back to tab navigation

Article information


Submitted
17 Oct 2019
First published
12 Dec 2019

Chem. Soc. Rev., 2020,49, 286-300
Article type
Review Article

Chiral phosphoric acid-catalyzed asymmetric dearomatization reactions

Z. Xia, Q. Xu-Xu, C. Zheng and S. You, Chem. Soc. Rev., 2020, 49, 286
DOI: 10.1039/C8CS00436F

Social activity

Search articles by author

Spotlight

Advertisements