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Hydration of sulfobetaine dizwitterions as a function of alkyl spacer length

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Abstract

The solvation and structure of bolaform dizwitterions containing two sulfobetaine moieties in concentrated aqueous solution were determined using neutron diffraction with isotopic substitution (NDIS) combined with modelling of the measured structure factors using Empirical Potential Structure Refinement (EPSR). Strongly directional local hydration was observed in the polar regimes of the dizwitterions with 48–52 water molecules shared between dizwitterion molecules in a first shell water network around each zwitterion pair. Overall, the double zwitterions were highly hydrated, providing experimental evidence in support of the potential formation of protein-resistant hydration layers at zwitterion–water interfaces.

Graphical abstract: Hydration of sulfobetaine dizwitterions as a function of alkyl spacer length

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Article information


Submitted
15 May 2020
Accepted
28 Jun 2020
First published
29 Jun 2020

This article is Open Access

Phys. Chem. Chem. Phys., 2020, Advance Article
Article type
Paper

Hydration of sulfobetaine dizwitterions as a function of alkyl spacer length

O. S. Hammond, L. Moura, G. Level, S. Imberti, J. D. Holbrey and M. Blesic, Phys. Chem. Chem. Phys., 2020, Advance Article , DOI: 10.1039/D0CP02654A

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