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Issue 29, 2020
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Optical properties of photodynamic therapy drugs in different environments: the paradigmatic case of temoporfin

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Abstract

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) – a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based on the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into cells, is fundamental to achieve the desired effect on malignant tissues via PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments – in vacuo, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Graphical abstract: Optical properties of photodynamic therapy drugs in different environments: the paradigmatic case of temoporfin

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Supplementary files

Article information


Submitted
16 Apr 2020
Accepted
24 Jun 2020
First published
16 Jul 2020

This article is Open Access

Phys. Chem. Chem. Phys., 2020,22, 16956-16964
Article type
Paper

Optical properties of photodynamic therapy drugs in different environments: the paradigmatic case of temoporfin

B. Aslanoglu, I. Yakavets, V. Zorin, H. Lassalle, F. Ingrosso, A. Monari and S. Catak, Phys. Chem. Chem. Phys., 2020, 22, 16956
DOI: 10.1039/D0CP02055A

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