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Issue 7, 2020
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Surface plasmon resonance study of the interaction of N-methyl mesoporphyrin IX with G-quadruplex DNA

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Abstract

Surface plasmon resonance (SPR) was used to investigate the interaction between N-methyl mesoporphyrin IX (NMM) and different G-quadruplex (G4) topologies. The study was associated with circular dichroism analysis (CD) to assess the topology of the G4s when they interacted with NMM. We demonstrate the high selectivity of NMM for the parallel G4 structure with a dissociation constant at least ten times lower than those of other G4 topologies. We also confirm the ability of NMM to shift the G4 conformation from both the hybrid and antiparallel topologies toward the parallel structure.

Graphical abstract: Surface plasmon resonance study of the interaction of N-methyl mesoporphyrin IX with G-quadruplex DNA

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Supplementary files

Article information


Submitted
22 Nov 2019
Accepted
02 Feb 2020
First published
06 Feb 2020

Phys. Chem. Chem. Phys., 2020,22, 4158-4164
Article type
Paper

Surface plasmon resonance study of the interaction of N-methyl mesoporphyrin IX with G-quadruplex DNA

M. Perenon, H. Bonnet, T. Lavergne, J. Dejeu and E. Defrancq, Phys. Chem. Chem. Phys., 2020, 22, 4158
DOI: 10.1039/C9CP06321H

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