Issue 16, 2020
From the journal:

CrystEngComm

Discovery of new polymorphs of the tuberculosis drug isoniazid†

Keke Zhang,‡ab   Noalle Fellah,‡a   Alexander G. Shtukenberg, ORCID logo a   Xiaoyan Fu,c   Chunhua Hu ORCID logo a  and  Michael D. Ward ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Molecular Design Institute, New York University, New York City, NY, USA
E-mail: mdw3@nyu.edu

b School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, People's Republic of China

c State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, People's Republic of China

Abstract

Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement. The two new forms are readily distinguished from the known form by optical microscopy, Raman spectroscopy and X-ray powder diffraction. A single crystal structure was obtained for one of the new polymorphs.

Graphical abstract: Discovery of new polymorphs of the tuberculosis drug isoniazid

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Article information

DOI
https://doi.org/10.1039/D0CE00440E
Article type
Communication
Submitted
22 Mar 2020
Accepted
27 Mar 2020
First published
08 Apr 2020

CrystEngComm, 2020,22, 2705-2708

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Discovery of new polymorphs of the tuberculosis drug isoniazid

K. Zhang, N. Fellah, A. G. Shtukenberg, X. Fu, C. Hu and M. D. Ward, CrystEngComm, 2020, 22, 2705 DOI: 10.1039/D0CE00440E

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