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Structural similarity in chiral-achiral multi-component crystals

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Abstract

The creation of multi-component crystals between chiral and achiral components has gained increased interest in recent years. In many cases the overall crystal structure is similar with the creation of a pseudo-inversion centre in the enantiopure case. This allows for the formation of solid solutions between the two extremes, which may have applications within chiral resolution. Utilising a combination of database mining, computational prediction and experimental screening, the frequency of formation for such materials has been investigated showing that for co-crystals this occurs more frequently than for salts, though there is a limited number of samples to draw structural conclusions. Computational modelling indicates the prediction of such systems can be challenging due to the similarities in energy of many crystal structures, so development of tools to design such systems is required to fully utilise these concepts.

Graphical abstract: Structural similarity in chiral-achiral multi-component crystals

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Article information


Submitted
28 Feb 2020
Accepted
15 Apr 2020
First published
15 Apr 2020

CrystEngComm, 2020, Advance Article
Article type
Paper

Structural similarity in chiral-achiral multi-component crystals

I. J. Scowen, T. S. Alomar, T. Munshi and C. C. Seaton, CrystEngComm, 2020, Advance Article , DOI: 10.1039/D0CE00301H

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