Issue 18, 2020
From the journal:

CrystEngComm

The axial chirality hidden in vitamin D and its application in cocrystal prediction†

Mengfei Guo,a   Zaiyong Zhang,b   Zhaoqiang Chen,b   Qiaoce Ding,b   Liye Lu,b   Qi Zhang,b   Jian-Rong Wang ORCID logo *b  and  Xuefeng Mei ORCID logo *b  

* Corresponding authors

a College of Pharmacy, Nanchang University, Nanchang 330006, China

b Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: jrwang@simm.ac.cn, xuefengmei@simm.ac.cn
Fax: +862150807088
Tel: +862150800934

Abstract

The axial chirality of the non-planar conjugated triene in vitamin D3 was uncovered for the first time. An ECD titration method was used not only for conformational analysis of vitamin D but also for sensitive detection of hydrogen-bonding interaction in solution. It provides a sensitive approach to predict cocrystal formation.

Graphical abstract: The axial chirality hidden in vitamin D and its application in cocrystal prediction

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Article information

DOI
https://doi.org/10.1039/D0CE00229A
Article type
Communication
Submitted
15 Feb 2020
Accepted
25 Mar 2020
First published
26 Mar 2020

CrystEngComm, 2020,22, 3095-3099

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The axial chirality hidden in vitamin D and its application in cocrystal prediction

M. Guo, Z. Zhang, Z. Chen, Q. Ding, L. Lu, Q. Zhang, J. Wang and X. Mei, CrystEngComm, 2020, 22, 3095 DOI: 10.1039/D0CE00229A

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