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The axial chirality hidden in vitamin D and its application in cocrystal prediction

Abstract

The axial chirality of non-planar conjugated triene in vitamin D3 was uncovered for the first time. ECD titration method was used not only for conformational analysis of vitamin D but also for sensitive detection of hydrogen-bonding interaction in solution. It provides a sensitive approach to predict cocrystal formation.

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Article information


Submitted
15 Feb 2020
Accepted
25 Mar 2020
First published
26 Mar 2020

CrystEngComm, 2020, Accepted Manuscript
Article type
Communication

The axial chirality hidden in vitamin D and its application in cocrystal prediction

M. Guo, Z. Zhang, Z. Chen, Q. Ding, L. Lu, Q. Zhang, J. Wang and X. Mei, CrystEngComm, 2020, Accepted Manuscript , DOI: 10.1039/D0CE00229A

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