Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 20, 2020
Previous Article Next Article

Growth kinetics of curcumin form I

Author affiliations

Abstract

The growth rate of pure curcumin particles (CUR) in supersaturated propan-2-ol solutions has been determined by seeded isothermal desupersaturation experiments at different temperatures (283–318 K). In situ ATR UV-vis and FBRM were used to monitor the solution concentration over time and to verify that no nucleation was occurring. Principal component analysis (PCA) was applied to the UV-vis spectra to determine the supersaturation decay over time. The growth rate is examined by fitting the power law empirical models and the Burton Cabrera Frank (BCF) and birth and spread (B + S) mechanistic models to the experimental desupersaturation data. The growth rate is low, and the growth order (1.75) and the activation energy (38 kJ mol−1) are high, all suggesting that growth is surface integration controlled. Fitting the B + S model, the solid–liquid interfacial energy is estimated to be 2.7 mJ m−2. Approximate surface diffusion rates are extracted and the mean surface diffusion distance is estimated to be 2 nm. The growth rate is clearly lower than that found for other compounds of lower molecular weight. This originates from a higher interfacial surface energy and a slower surface diffusion.

Graphical abstract: Growth kinetics of curcumin form I

Back to tab navigation

Supplementary files

Article information


Submitted
09 Jan 2020
Accepted
15 Apr 2020
First published
15 Apr 2020

CrystEngComm, 2020,22, 3505-3518
Article type
Paper

Growth kinetics of curcumin form I

C. Heffernan, R. Soto, B. K. Hodnett and Å. C. Rasmuson, CrystEngComm, 2020, 22, 3505
DOI: 10.1039/D0CE00034E

Social activity

Search articles by author

Spotlight

Advertisements