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Metal-Organic Framework Tethering pH- and Thermo-Responsive Polymer for ON-OFF Controlled Release of the Guest Molecules

Abstract

The controlled release of small molecules from carrier materials by manipulating the environmental conditions has potential for use in drug delivery. In the present study, we demonstrate the controlled release of a guest molecule (procainamide) from a metal–organic framework (MOF). The MOF is covered with a copolymer of N-isopropyl acrylamide (NIPAM) and acrylic acid (AA) by post-synthetic modification. The polymer exhibits rapid and reversible coil–globule transition that is both pH- and thermoresponsive, thereby allowing the guest molecule to be released from the MOF in an “on-off” manner. At high pH (6.86) or low temperature (< 25 °C) — when the polymer adopts a coil conformation — the guest molecule is rapidly released from the MOF, whereas at low pH (4.01) or high temperature (> 40 °C) — when the polymer adopts a globule conformation — the release of the guest is suppressed. The release can be halted by the applying the external stimuli even after starting the release. The MOF-derived controllable container introduced here will facilitate targeted drug delivery and the controlled release of therapeutic agents.

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Supplementary files

Article information


Submitted
01 Nov 2019
Accepted
13 Dec 2019
First published
23 Dec 2019

CrystEngComm, 2020, Accepted Manuscript
Article type
Paper

Metal-Organic Framework Tethering pH- and Thermo-Responsive Polymer for ON-OFF Controlled Release of the Guest Molecules

S. Nagata, K. Kokado and K. Sada, CrystEngComm, 2020, Accepted Manuscript , DOI: 10.1039/C9CE01731C

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