Jump to main content
Jump to site search


Probing the distinct nanomechanical behaviour of a new co-crystal and a known solvate of 5-fluoroisatin and identification of a new polymorph

Author affiliations

Abstract

New crystalline forms (a polymorph and a co-crystal) and a previously reported solvate of the parent compound 5-fluoroisatin have been characterized by thermal, structural, and computational methods. The mechanical responses (hardness, H, and elastic modulus, E) of the co-crystal and the solvate have been characterized using nanoindentation experiments on the major faces. Results show that H and E of the solvated form of the molecule are 11 and 13 fold higher than those of the co-crystal, respectively. Energy decomposition analyses have been performed on these crystal structures to understand the primary building blocks and the role of different intermolecular interaction energies in the observed nanomechanical properties. These suggest that a nearly similar layered interaction topology of molecules is present in both the co-crystal and the solvated form. Interestingly, the presence of relatively strong interlayer interactions of molecules in the solvate prevents long-range molecular layer migration, which minimizes the scope for plastic deformation in comparison to the co-crystal.

Graphical abstract: Probing the distinct nanomechanical behaviour of a new co-crystal and a known solvate of 5-fluoroisatin and identification of a new polymorph

Back to tab navigation

Supplementary files

Article information


Submitted
21 Oct 2019
Accepted
28 Feb 2020
First published
02 Mar 2020

CrystEngComm, 2020, Advance Article
Article type
Paper

Probing the distinct nanomechanical behaviour of a new co-crystal and a known solvate of 5-fluoroisatin and identification of a new polymorph

P. K. Mondal, S. Bhandary, M. G. Javoor, A. Cleetus, S. R. N. K. Mangalampalli, U. Ramamurty and D. Chopra, CrystEngComm, 2020, Advance Article , DOI: 10.1039/C9CE01659G

Social activity

Search articles by author

Spotlight

Advertisements