Issue 87, 2020

Translation-coupled RNA replication and parasitic replicators in membrane-free compartments

Abstract

We report RNA self-replication through the translation of its encoded protein within membrane-free compartments generated by liquid–liquid phase separation. The aqueous droplets support RNA self-replication by concentrating a genomic RNA and translation proteins, facilitating the uptake of small substrates, and preventing the replication of parasitic RNAs through compartmentalization.

Graphical abstract: Translation-coupled RNA replication and parasitic replicators in membrane-free compartments

Supplementary files

Article information

Article type
Communication
Submitted
02 Oct 2020
Accepted
06 Oct 2020
First published
07 Oct 2020
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 13453-13456

Translation-coupled RNA replication and parasitic replicators in membrane-free compartments

R. Mizuuchi and N. Ichihashi, Chem. Commun., 2020, 56, 13453 DOI: 10.1039/D0CC06606K

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