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Copper-Catalyzed Oxidative Decarboxylative Alkylation of Cinnamic Acids with 4-Alkyl-1,4-dihydropyridines

Abstract

We have developed a new oxidative decarboxylation of cinnamic acids with 4-alkyl-1,4-dihydropyridines to construct C(sp3)-C(sp2) bond in the presence of copper catalyst and dicumyl peroxide (DCP). A variety of internal alkenes have been obtained with mild condition, broad substrates scope and excellent functional groups tolerance. This method has significant potential for application by using inexpensive and stable cinnamic acids instead of alkenyl halides and nitro-olefins.

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Article information


Submitted
23 Sep 2020
Accepted
16 Oct 2020
First published
16 Oct 2020

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Copper-Catalyzed Oxidative Decarboxylative Alkylation of Cinnamic Acids with 4-Alkyl-1,4-dihydropyridines

D. Zhang, Z. Tang, X. Ouyang, R. Song and J. Li, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC06401G

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