Li-Song Zhang, Li-Xin Yan, Shan Gao, Hui Long, Zhen Xi, Lu-Yuan Li and Zhi-Song Zhang
Chem. Commun., 2020,56, 15321-15324
DOI:
10.1039/D0CC06387H,
Communication
We developed a new strategy to overcome the MDR of etoposide using self-assembling nanofibers. Compared with the original etoposide, the inhibitory activity of Nap-GFFpYK-etoposide1/2 against murine Lewis lung cancer or breast cancer cells was increased 10 times, and 20 times on these cells with artificially overexpressed MDR1. Our method to synthesize and separate etoposide isomers provides a new strategy for the modification of this drug.
