Issue 92, 2020

Reversible hydrogen-bonded polymerization regulated by allosteric metal templation

Abstract

Allosteric effects are common in biology, but have not been fully explored in the control of supramolecular polymerization. Herein, ditopic UPy derivatives with acyclic crown ether-like spacers were designed and synthesized, which can undergo supramolecular polymerization through quadruple hydrogen bonding. Upon the addition of K+, drastic molecular conformational change to the U-shape is induced by metal-coordination, reconfiguring remote UPy sites towards the formation of discrete cyclic dimers. Interestingly, the supramolecular polymerization can be restored by simply removing K+ by water-extraction.

Graphical abstract: Reversible hydrogen-bonded polymerization regulated by allosteric metal templation

Supplementary files

Article information

Article type
Communication
Submitted
23 Sep 2020
Accepted
27 Oct 2020
First published
27 Oct 2020

Chem. Commun., 2020,56, 14385-14388

Reversible hydrogen-bonded polymerization regulated by allosteric metal templation

T. Xiao, W. Zhong, W. Yang, L. Qi, Y. Gao, A. C.-H. Sue, Z. Li, X. Sun, C. Lin and L. Wang, Chem. Commun., 2020, 56, 14385 DOI: 10.1039/D0CC06381A

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