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Issue 92, 2020
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Ultrastable radical-doped coordination compounds with antimicrobial activity against antibiotic-resistant bacteria

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Abstract

In the present work, we have introduced a series of stable radical-doped coordination compounds composed of donor–acceptor structures and shown to produce organic radicals in situ as a result of unconventional lone pair–π interactions in ambient conditions. Inconspicuous lone pair–π and C–H⋯π interactions were shown to play a key role in self-assembly as well as the charge transfer process, resulting in a long-lived charge-separated state able to generate organic radicals. The resultant species displayed broad-spectrum antimicrobial activity, including against multi-drug-resistant bacteria. This study unveiled the promise of reactive organic radical-doped materials as a new platform for developing antimicrobial agents that can overcome antibiotic resistance.

Graphical abstract: Ultrastable radical-doped coordination compounds with antimicrobial activity against antibiotic-resistant bacteria

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Article information


Submitted
23 Sep 2020
Accepted
23 Oct 2020
First published
24 Oct 2020

Chem. Commun., 2020,56, 14353-14356
Article type
Communication

Ultrastable radical-doped coordination compounds with antimicrobial activity against antibiotic-resistant bacteria

H. Ke, F. Hu, L. Meng, Q. Chen, Q. Lai, Z. Li, Z. Huang, J. Liao, J. Qiu and C. Lu, Chem. Commun., 2020, 56, 14353
DOI: 10.1039/D0CC06379G

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