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A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides

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Abstract

Hydrophilic Fe3O4@PDA@UIO-66-NH2 is employed to consecutively enrich urinary exosomes and exosomal phosphopeptides through the strong bond between Zr and phosphate groups. The recovery of exosomes reached 95% and 707 phosphopeptides were identified from 255 phosphoproteins via LC-MS/MS. This work will make a great contribution to further functional analysis of exosomes.

Graphical abstract: A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides

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Article information


Submitted
11 Sep 2020
Accepted
07 Oct 2020
First published
07 Oct 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides

N. Zhang, N. Sun and C. Deng, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC06147F

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