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An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines

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Abstract

Herein, a new fluorescent probe, AE-Phos, is reported for detecting the ALP activity with the combined advantages of aggregation-induced emission (AIE) and excited state intramolecular proton transfer (ESIPT). Further detailed fluorescence experiments demonstrated that AE-Phos exhibited excellent selectivity and sensitivity, a large Stokes shift, and a fast response towards ALP. Furthermore, AE-Phos was applied to imaging the ALP activity in different cell lines quantitatively.

Graphical abstract: An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines

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Article information


Submitted
10 Sep 2020
Accepted
29 Sep 2020
First published
30 Sep 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines

Y. He, J. Yu, X. Hu, S. Huang, L. Cai, L. Yang, H. Zhang, Y. Jiang, Y. Jia and H. Sun, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC06129H

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