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A simple and sensitive method for exosome detection based on steric hindrance-controlled signal amplification

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Abstract

Exosomes have been widely considered as excellent noninvasive or minimally invasive biomarkers; however, the currently available methods for exosome detection usually need sophisticated instruments, or the sensitivity cannot be satisfactory, since the size of exosomes is very large. Nevertheless, in this work, by making use of the steric hindrance of exosomes due to their large size, we have developed a simple and sensitive method for the detection of exosomes with great potential in clinical use.

Graphical abstract: A simple and sensitive method for exosome detection based on steric hindrance-controlled signal amplification

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Article information


Submitted
10 Sep 2020
Accepted
13 Oct 2020
First published
14 Oct 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

A simple and sensitive method for exosome detection based on steric hindrance-controlled signal amplification

Y. Pan, L. Wang, Y. Deng, M. Wang, Y. Peng, J. Yang and G. Li, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC06113A

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