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Issue 87, 2020
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On the reactivity of mRNA Cap0: C–H oxidative addition of 7-methylguanosine to Pt0 and base pairing studies

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Abstract

7-Methylguanosine, whose lability to form an ylide/NHC has been known for decades, reacts with [Pt(PPh3)4] via C–H oxidative addition to yield a hydrido–PtII carbene complex. 1H NMR studies on Watson–Crick base-pairs showed no significant effect of metallation.

Graphical abstract: On the reactivity of mRNA Cap0: C–H oxidative addition of 7-methylguanosine to Pt0 and base pairing studies

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Article information


Submitted
09 Sep 2020
Accepted
02 Oct 2020
First published
05 Oct 2020

Chem. Commun., 2020,56, 13365-13368
Article type
Communication

On the reactivity of mRNA Cap0: C–H oxidative addition of 7-methylguanosine to Pt0 and base pairing studies

M. I. P. S. Leitão, C. Gonzalez, G. Francescato, Z. Filipiak and A. Petronilho, Chem. Commun., 2020, 56, 13365
DOI: 10.1039/D0CC06075E

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