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Fluorescence resonance energy transfer-based DNA framework assembled split G-quadruplex nanodevices for microRNA sensing

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Abstract

A DNA framework assembled split G4 nanodevice was fabricated to realize microRNA imaging in living HeLa cells. After hybridization with the target, the separated G4 segments underwent structural transformations, which could initiate fluorescence resonance energy transfer (FRET) processes. Our design may pave a novel way to facilitate applications of the G4 motif.

Graphical abstract: Fluorescence resonance energy transfer-based DNA framework assembled split G-quadruplex nanodevices for microRNA sensing

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Article information


Submitted
08 Sep 2020
Accepted
01 Oct 2020
First published
14 Oct 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Fluorescence resonance energy transfer-based DNA framework assembled split G-quadruplex nanodevices for microRNA sensing

G. Su, M. Zhu, M. Xu, J. Pan, Y. Zhou, H. Zhou, W. S. Zhang, Y. Tong and Y. Yu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC06054B

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