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Copper and palladium co-catalyzed highly regio-selective 1,2-hydroarylation of terminal 1,3-dienes

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Abstract

A practical copper and palladium co-catalyzed highly regio-selective hydroarylation of terminal 1,3-dienes has been developed. This chemistry afforded the terminal alkenyl group containing products, which are a kind of versatile precursor for organic synthesis, from 1,3-dienes by a practical one-step reaction. With good functional group tolerance, this protocol could be used to make a series of bio-active compounds using readily accessible starting materials. The mechanism of this reaction was explored by control experiments and kinetics studies.

Graphical abstract: Copper and palladium co-catalyzed highly regio-selective 1,2-hydroarylation of terminal 1,3-dienes

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Article information


Submitted
06 Sep 2020
Accepted
02 Oct 2020
First published
05 Oct 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Copper and palladium co-catalyzed highly regio-selective 1,2-hydroarylation of terminal 1,3-dienes

R. Zhang, Q. Li, M. Zhang, S. Chai, Y. Duan, J. Su, Q. Zhao and C. Zhang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC06007K

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