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Target-induced molecular-switch on triple-helix DNA-functionalized carbon nanotubes for simultaneous visual detection of nucleic acids and proteins

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Abstract

We report an easy and efficient approach based on a target-induced molecular-switch on triple-helix DNA (THD)-functionalized carbon nanotubes (CNTs) for the simultaneous visual detection of nucleic acids and proteins with a lateral flow nucleic acid biosensor. The assay had the capability to detect a minimum of 25 pM target DNA and 0.25 nM thrombin simultaneously within 20 min.

Graphical abstract: Target-induced molecular-switch on triple-helix DNA-functionalized carbon nanotubes for simultaneous visual detection of nucleic acids and proteins

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Article information


Submitted
04 Sep 2020
Accepted
08 Oct 2020
First published
09 Oct 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Target-induced molecular-switch on triple-helix DNA-functionalized carbon nanotubes for simultaneous visual detection of nucleic acids and proteins

Y. Huang, Z. Cheng, R. Han, X. Gao, L. Qian, Y. Wen, X. Zhang and G. Liu, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC05986B

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