Issue 88, 2020
From the journal:

Chemical Communications

Target-induced molecular-switch on triple-helix DNA-functionalized carbon nanotubes for simultaneous visual detection of nucleic acids and proteins†

Yan Huang,ab   Zhihao Cheng,a   Rong Han,a   Xuan Gao,a   Lisheng Qian,*a   Yongqiang Wen, ORCID logo b   Xueji Zhang ORCID logo *bc  and  Guodong Liu ORCID logo *a  

* Corresponding authors

a Research Center for Biomedical and Health Science, Anhui Science and Technology University, Fengyang 233100, P. R. China
E-mail: qianls@ahstu.edu.cn, liugd@ahstu.edu.cn

b Key lab for Bioengineering and Sensing Technology, University of Science & Technology Beijing, Beijing, P. R. China
E-mail: zhangxueji@ustb.edu.cn

c School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China

Abstract

We report an easy and efficient approach based on a target-induced molecular-switch on triple-helix DNA (THD)-functionalized carbon nanotubes (CNTs) for the simultaneous visual detection of nucleic acids and proteins with a lateral flow nucleic acid biosensor. The assay had the capability to detect a minimum of 25 pM target DNA and 0.25 nM thrombin simultaneously within 20 min.

Graphical abstract: Target-induced molecular-switch on triple-helix DNA-functionalized carbon nanotubes for simultaneous visual detection of nucleic acids and proteins

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Article information

DOI
https://doi.org/10.1039/D0CC05986B
Article type
Communication
Submitted
04 Sep 2020
Accepted
08 Oct 2020
First published
09 Oct 2020

Chem. Commun., 2020,56, 13657-13660

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Target-induced molecular-switch on triple-helix DNA-functionalized carbon nanotubes for simultaneous visual detection of nucleic acids and proteins

Y. Huang, Z. Cheng, R. Han, X. Gao, L. Qian, Y. Wen, X. Zhang and G. Liu, Chem. Commun., 2020, 56, 13657 DOI: 10.1039/D0CC05986B

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