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Issue 83, 2020
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Visible-light-mediated photoredox minisci C–H alkylation with alkyl boronic acids using molecular oxygen as an oxidant

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Abstract

Herein, we report a protocol for direct visible-light-mediated Minisci C–H alkylation reactions of heteroarenes with alkyl boronic acids using molecular oxygen as the sole oxidant. This mild protocol uses an inexpensive, green oxidant; permits efficient functionalization of various N-heteroarenes with a broad range of primary and secondary alkyl boronic acids; and is scalable to the gram level. We demonstrated the practicality and sustainability of the protocol by preparing or functionalizing several pharmaceuticals and natural products.

Graphical abstract: Visible-light-mediated photoredox minisci C–H alkylation with alkyl boronic acids using molecular oxygen as an oxidant

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Supplementary files

Article information


Submitted
03 Sep 2020
Accepted
14 Sep 2020
First published
16 Sep 2020

Chem. Commun., 2020,56, 12652-12655
Article type
Communication

Visible-light-mediated photoredox minisci C–H alkylation with alkyl boronic acids using molecular oxygen as an oxidant

J. Dong, F. Yue, H. Song, Y. Liu and Q. Wang, Chem. Commun., 2020, 56, 12652
DOI: 10.1039/D0CC05946C

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