Jump to main content
Jump to site search


Chemical synthesis of α(2,8) octasialosides, the minimum structure of polysialic acids

Author affiliations

Abstract

Chemical synthesis of an α(2,8) octasialic acid by using an N-acetyl-5-N,4-O:7-O,9-O-dicarbonyl protected sialyl donor is reported. The glycosyl donor underwent α-selective sialylation at the C8 hydroxyl group to give α(2,8) sialyl oligomers. The resulting oligosaccharides were then deprotected to give the fully deprotected α(2,8) octasialic acid without lacking the N-acetyl groups.

Graphical abstract: Chemical synthesis of α(2,8) octasialosides, the minimum structure of polysialic acids

Back to tab navigation

Supplementary files

Article information


Submitted
01 Sep 2020
Accepted
21 Sep 2020
First published
22 Sep 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Chemical synthesis of α(2,8) octasialosides, the minimum structure of polysialic acids

R. Koinuma, K. Tohda, T. Aoyagi and H. Tanaka, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC05901C

Social activity

Search articles by author

Spotlight

Advertisements