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Issue 85, 2020
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Ligand-free copper-catalyzed regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes

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Abstract

The copper-catalyzed highly regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes with α-chloroacetamides and dialkyl 2-fluoromalonate or 2-fluoro-N,N-dialkyl-3-oxobutanamide without an external ligand has been realized. With this novel methodology, (E)-β-monofluoroalkyl-β,γ-unsaturated amides containing quaternary C–F centers can be easily constructed in good to excellent yields.

Graphical abstract: Ligand-free copper-catalyzed regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes

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Article information


Submitted
31 Aug 2020
Accepted
21 Sep 2020
First published
22 Sep 2020

Chem. Commun., 2020,56, 12933-12936
Article type
Communication

Ligand-free copper-catalyzed regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes

Y. Lv, W. Pu and X. Wang, Chem. Commun., 2020, 56, 12933
DOI: 10.1039/D0CC05887D

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