Efficient temperature-feedback liposome for 19F MRI signal enhancement

Lili Ren; Shizhen Chen; Weiping Jiang; Qingbin Zeng; Xu Zhang; Long Xiao; Michael T. McMahon; Lou Xin; Xin Zhou

doi:10.1039/D0CC05809B

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Efficient temperature-feedback liposome for ¹⁹F MRI signal enhancement†

Lili Ren,‡^ab Shizhen Chen,‡*^a Weiping Jiang,^a Qingbin Zeng,^a Xu Zhang,^a Long Xiao,^a Michael T. McMahon,^c Lou Xin^d and Xin Zhou

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan National Laboratory for Optoelectronics, 430071, Wuhan, China
E-mail: xinzhou@wipm.ac.cn, chenshizhen@wipm.ac.cn

^b Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China

^c Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute Baltimore, Maryland 21287, USA

^d Department of Radiology, Chinese PLA General Hospital, Beijing, China

Abstract

A new non-encapsulated fluorinated liposome (TSL) was developed, which showed instantaneous temperature-induced ¹⁹F MR signal enhancement and excellent stability under reversible signal transition at different conditions.

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Article information

DOI: https://doi.org/10.1039/D0CC05809B
Article type: Communication
Submitted: 27 Aug 2020
Accepted: 25 Oct 2020
First published: 27 Oct 2020

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Chem. Commun., 2020,56, 14427-14430

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Efficient temperature-feedback liposome for ¹⁹F MRI signal enhancement

L. Ren, S. Chen, W. Jiang, Q. Zeng, X. Zhang, L. Xiao, M. T. McMahon, L. Xin and X. Zhou, Chem. Commun., 2020, 56, 14427 DOI: 10.1039/D0CC05809B

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Chemical Communications