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Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy

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Abstract

We conceptually demonstrate single-cell infrared phenomics as a novel strategy of phenotypic screening with infrared microspectroscopy. Based on this development, the cancer cell HepG2 glycocalyx was first identified as a potential target of protopanaxadiol, an herbal medicine. These findings provide a powerful tool to accurately evaluate the cell stress response and to largely expand the phenotypic screening toolkit for drug discovery.

Graphical abstract: Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy

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Article information


Submitted
23 Aug 2020
Accepted
29 Sep 2020
First published
29 Sep 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy

Y. Wang, Y. Wang, J. Qian, X. Pan, X. Li, F. Chen, J. Hu and J. Lü, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC05721E

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