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Issue 87, 2020
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A bimolecular i-motif mediated FRET strategy for imaging protein homodimerization on a living tumor cell surface

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Abstract

A bimolecular i-motif mediated FRET strategy was developed based on the proximity-induced folding of two identical cytosine-rich DNA strands. This strategy affords a FRET signal that is highly matched to the dimerization event, and enabled accurate and dynamic in situ imaging of Met homodimerization on a living tumor cell surface.

Graphical abstract: A bimolecular i-motif mediated FRET strategy for imaging protein homodimerization on a living tumor cell surface

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Article information


Submitted
18 Aug 2020
Accepted
21 Sep 2020
First published
21 Sep 2020

Chem. Commun., 2020,56, 13405-13408
Article type
Communication

A bimolecular i-motif mediated FRET strategy for imaging protein homodimerization on a living tumor cell surface

A. Kan, X. Liu, X. Xu, N. Zhang and W. Jiang, Chem. Commun., 2020, 56, 13405
DOI: 10.1039/D0CC05607C

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