Phen-DC3 is among the most commonly used G-quadruplex (G4)-stabilizers in vitro and in cells. Here, we show that the G4-interactive binding interactions enable one to tune the optical properties of Phen-DC3 allowing the detection of G4 structures in cancer cells. This work opens up new directions for the use of Phen-DC3 as a selective G4 fluorescent reporter.
M. Deiana, J. Jamroskovic, I. Obi and N. Sabouri, Chem. Commun., 2020, 56, 14251 DOI: 10.1039/D0CC05483F
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