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Unravelling the Cellular Emission Fingerprint of the Benchmark G-Quadruplex-Interactive Compound Phen-DC3

Abstract

Phen-DC3 is among the most commonly used G-quadruplex (G4)-stabilizers in vitro and in cells. Here we show, that the G4-interactive binding interactions enable to tune Phen-DC3’s optical properties allowing the detection of G4 structures in cancer cells. This work opens up new directions for the use of Phen-DC3 as a selective G4 fluorescent reporter.

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Supplementary files

Article information


Submitted
12 Aug 2020
Accepted
16 Oct 2020
First published
16 Oct 2020

This article is Open Access

Chem. Commun., 2020, Accepted Manuscript
Article type
Communication

Unravelling the Cellular Emission Fingerprint of the Benchmark G-Quadruplex-Interactive Compound Phen-DC3

M. Deiana, J. Jamroskovic, I. Obi and N. Sabouri, Chem. Commun., 2020, Accepted Manuscript , DOI: 10.1039/D0CC05483F

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