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Designing inhalable metal organic frameworks for pulmonary tuberculosis treatment and theragnostics via spray drying

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Abstract

Inhalable metal organic framework (MOF) aerosols have been developed via spray drying as a therapy for multi-drug resistant (MDR) tuberculosis (TB). The CuPOA2 (pyrazinoate acid) MOFs can be tailored to exhibit a respirable mass median aerodynamic diameter (MMAD) of 2.6 μm. This method is repeated to manufacture Gd0.1Cu0.9(POA)2 MOFs for inhalable theragnostics.

Graphical abstract: Designing inhalable metal organic frameworks for pulmonary tuberculosis treatment and theragnostics via spray drying

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Supplementary files

Article information


Submitted
11 Aug 2020
Accepted
28 Sep 2020
First published
29 Sep 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Designing inhalable metal organic frameworks for pulmonary tuberculosis treatment and theragnostics via spray drying

I. Luz, I. E. Stewart, N. P. Mortensen and A. J. Hickey, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC05471B

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