Issue 90, 2020
From the journal:

Chemical Communications

Nitric oxide-releasing platinum(iv) prodrug efficiently inhibits proliferation and metastasis of cancer cells†

Yi Dai,‡ab   Yang Zhu, ORCID logo ‡a   Junjie Cheng, ORCID logo *a   Juan Shen,a   Hai Huang, ORCID logo a   Manman Liu,a   Zhaolin Chenc  and  Yangzhong Liu ORCID logo *a  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China
E-mail: liuyz@ustc.edu.cn

b College of Pharmaceutical Sciences, Anhui Xinhua University, Hefei, Anhui, China

c The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Department of Pharmacy, University of Science and Technology of China, Hefei, Anhui, China

Abstract

A dual-functional Pt(IV) prodrug, Pt–furoxan, can release cytotoxic cisplatin and signaling molecule NO upon cellular internalization. NO modulates the cellular response towards cisplatin, leading to a synergistic anti-proliferation effect and a promising anti-metastasis effect both in vitro and in vivo.

Graphical abstract: Nitric oxide-releasing platinum(iv) prodrug efficiently inhibits proliferation and metastasis of cancer cells

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Article information

DOI
https://doi.org/10.1039/D0CC05422D
Article type
Communication
Submitted
09 Aug 2020
Accepted
14 Oct 2020
First published
15 Oct 2020

Chem. Commun., 2020,56, 14051-14054

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Nitric oxide-releasing platinum(IV) prodrug efficiently inhibits proliferation and metastasis of cancer cells

Y. Dai, Y. Zhu, J. Cheng, J. Shen, H. Huang, M. Liu, Z. Chen and Y. Liu, Chem. Commun., 2020, 56, 14051 DOI: 10.1039/D0CC05422D

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