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Issue 2, 2021
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Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis

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Abstract

The cross-coupling of aryl bromides with [11C]CH3Li for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3–5 min) compatible with the half-life of 11C (20.4 min). The automation of the protocol on a synthesis module is investigated, representing an important step towards a fast method for the synthesis of 11C-labelled compounds for PET imaging.

Graphical abstract: Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis

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Article information


Submitted
07 Aug 2020
Accepted
26 Nov 2020
First published
26 Nov 2020

Chem. Commun., 2021,57, 203-206
Article type
Communication

Cross-coupling of [11C]methyllithium for 11C-labelled PET tracer synthesis

H. Helbert, I. F. Antunes, G. Luurtsema, W. Szymanski, B. L. Feringa and P. H. Elsinga, Chem. Commun., 2021, 57, 203
DOI: 10.1039/D0CC05392A

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