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Precise engineering of apoferritin through site-specific host–guest binding

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Abstract

The surface engineering of the apoferritin shell by means of traditional chemical modifications usually suffers from site inaccuracy and insufficient conjugation. This report describes a non-covalent method for precise modulation of the apoferritin surface without alteration of amino acid residues. A bifunctional macromolecule, structured as azide–poly(ethylene glycol)–porphyrin (termed TPA), was synthesized. TPA was observed to be able to recognize and bind apoferritin in a 12 : 1 stoichiometry with a higher binding affinity than arachidonate, thanks to the specific host–guest interaction between the pocket of each two-fold channel and the porphyrin moiety. This method allows for site-specific engineering of the apoferritin surface with on demand functionalities and optimization of drug encapsulation.

Graphical abstract: Precise engineering of apoferritin through site-specific host–guest binding

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Supplementary files

Article information


Submitted
07 Aug 2020
Accepted
21 Sep 2020
First published
21 Sep 2020

Chem. Commun., 2020, Advance Article
Article type
Communication

Precise engineering of apoferritin through site-specific host–guest binding

X. Wang, K. Du, H. Heng, W. Chen, X. Li, X. Wei, F. Feng and S. Wang, Chem. Commun., 2020, Advance Article , DOI: 10.1039/D0CC05382A

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