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Issue 83, 2020
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Cobalt-catalyzed ring-opening addition of azabenzonorbornadienes via C(sp3)–H bond activation of 8-methylquinoline

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Abstract

The first ring-opening addition of a benzylic C(sp3)–H bond to azabenzonorbornadienes is demonstrated. The reaction proceeded under the catalytic system of [Cp*CoI2(CO)], AgSbF6 and Fe(OAc)2 in PhOMe. The methodology showed a good substrate scope with up to 96% yield. The relative configuration of the product was determined as cis-configuration by X-ray crystallography.

Graphical abstract: Cobalt-catalyzed ring-opening addition of azabenzonorbornadienes via C(sp3)–H bond activation of 8-methylquinoline

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Article information


Submitted
07 Aug 2020
Accepted
07 Sep 2020
First published
08 Sep 2020

Chem. Commun., 2020,56, 12570-12573
Article type
Communication

Cobalt-catalyzed ring-opening addition of azabenzonorbornadienes via C(sp3)–H bond activation of 8-methylquinoline

H. Tan, R. Khan, D. Xu, Y. Zhou, X. Zhang, G. Shi and B. Fan, Chem. Commun., 2020, 56, 12570
DOI: 10.1039/D0CC05374K

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