Issue 90, 2020
From the journal:

Chemical Communications

Rhamnose modified bovine serum albumin as a carrier protein promotes the immune response against sTn antigen†

Han Lin,‡a   Haofei Hong, ORCID logo ‡a   Jinfeng Wang,a   Chen Li,a   Zhifang Zhou ORCID logo *a  and  Zhimeng Wu ORCID logo *a  

* Corresponding authors

a The Key Laboratory of Carbohydrate Chemistry & Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China
E-mail: zhifangzhou@jiangnan.edu.cn, zwu@jiangnan.edu.cn
Fax: +86-510-85197582
Tel: +86-510-85197582

Abstract

Rhamnose and sTn antigen were co-conjugated to bovine serum albumin (BSA), a weakly immunogenic carrier protein, for cancer vaccine development. The immune responses against sTn have been significantly augmented with the involvement of Rha-specific antibodies to enhance antigen uptake.

Graphical abstract: Rhamnose modified bovine serum albumin as a carrier protein promotes the immune response against sTn antigen

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Article information

DOI
https://doi.org/10.1039/D0CC05263A
Article type
Communication
Submitted
02 Aug 2020
Accepted
12 Oct 2020
First published
12 Oct 2020

Chem. Commun., 2020,56, 13959-13962

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Rhamnose modified bovine serum albumin as a carrier protein promotes the immune response against sTn antigen

H. Lin, H. Hong, J. Wang, C. Li, Z. Zhou and Z. Wu, Chem. Commun., 2020, 56, 13959 DOI: 10.1039/D0CC05263A

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