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Issue 83, 2020
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Iron-promoted free radical cascade difunctionalization of unsaturated benzamides with silanes

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Abstract

Iron salt/peroxide promoted cascade difunctionalization of unsaturated benzamides with silanes has been reported. It provides a convenient, highly selective, and efficient protocol for the synthesis of various silylated dihydroisoquinolinones and 1,3-isoquinolinediones. In particular, the present methodology only gives cyclization products in good isolated yields under the typical conditions.

Graphical abstract: Iron-promoted free radical cascade difunctionalization of unsaturated benzamides with silanes

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Article information


Submitted
31 Jul 2020
Accepted
14 Sep 2020
First published
14 Sep 2020

Chem. Commun., 2020,56, 12656-12659
Article type
Communication

Iron-promoted free radical cascade difunctionalization of unsaturated benzamides with silanes

Y. Ge, Y. Tian, J. Wu, Q. Yan, L. Zheng, Y. Ren, J. Zhao and Z. Li, Chem. Commun., 2020, 56, 12656
DOI: 10.1039/D0CC05213B

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